# OnCo record idea-reg-non-viral-cart-manufacturing (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-reg-non-viral-cart-manufacturing/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-reg-non-viral-cart-manufacturing" ;
  schema:name "Non-viral CAR-T (transposon or CRISPR knock-in) as the default manufacturing route"@en ;
  schema:description "Putting the CAR gene into T cells without a virus removes the most expensive and delay-prone ingredient. Test whether non-viral products match viral ones."@en ;
  schema:url <https://onco.cc/ideas/idea-reg-non-viral-cart-manufacturing/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamaoncol.2018.0977> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/allogeneic-cell-therapy/> ;
  onco:targets <https://onco.cc/targets/cd19/> ;
  onco:trials <https://onco.cc/trials/nct04094311/>, <https://onco.cc/trials/reliance/>, <https://onco.cc/trials/talicel-phase-1-2/>, <https://onco.cc/trials/zuma-1/>, <https://onco.cc/trials/zuma-7/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-manufacturing-cell-therapy/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-hernandez-jama-oncol/>, <https://onco.cc/key-papers/paper-cd19-dlbcl-am-j-hematol-2021/>, <https://onco.cc/key-papers/paper-cd19-dlbcl-clin-cancer-res-2011/>, <https://onco.cc/key-papers/paper-cd19-dlbcl-cytotherapy-2020/> .