# OnCo record idea-reg-perioperative-propranolol-etodolac (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-reg-perioperative-propranolol-etodolac/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-reg-perioperative-propranolol-etodolac" ;
  schema:name "Perioperative beta-blocker plus COX-2 inhibitor to reduce metastasis after surgery"@en ;
  schema:description "Surgical stress releases catecholamines and prostaglandins that suppress anti-tumour immunity and help metastatic cells seed. Phase 2 trials of a five-day course of propranolol plus etodolac around breast and colorectal surgery shifted tumour markers of metastasis and immune suppression in the right direction; both drugs cost cents, and a publicly funded phase 3 is the missing step."@en ;
  schema:url <https://onco.cc/ideas/idea-reg-perioperative-propranolol-etodolac/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.3332/ecancer.2014.442> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-generic-repurposing/>, <https://onco.cc/bottlenecks/b-metastasis-biology/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-pantziarka-ecancermedicalscience/> .