# OnCo record idea-rejuv-biological-age-as-a-randomised-endpoint (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-rejuv-biological-age-as-a-randomised-endpoint/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-rejuv-biological-age-as-a-randomised-endpoint" ;
  schema:name "Put a biological-age marker in a trial that also measures something a person would notice"@en ;
  schema:description "Epigenetic clocks and senescence markers run fast after cancer treatment, and nobody has shown that moving one matters. The way to find out is to make the clock a secondary endpoint in a trial whose primary endpoint is physical function."@en ;
  schema:url <https://onco.cc/ideas/idea-rejuv-biological-age-as-a-randomised-endpoint/> ;
  schema:dateModified "2026-10-02"^^xsd:date ;
  schema:citation <https://doi.org/10.1093/jnci/djaa147>, <https://doi.org/10.1200/JCO.2013.52.2268>, <https://clinicaltrials.gov/study/NCT06113016> ;
  onco:tag "rejuvenation", "survivorship", "open-problem", "biological-ageing" ;
  onco:related <https://onco.cc/technologies/rejuv-age-epigenetic-clocks/>, <https://onco.cc/technologies/rejuv-age-senescent-cells-after-treatment/>, <https://onco.cc/technologies/rejuv-frontier-senolytics/>, <https://onco.cc/technologies/rejuv-frontier-what-works/>, <https://onco.cc/trials/rejuv-trial-proffi/>, <https://onco.cc/roadmaps/rejuvenation-roadmap/> ;
  onco:sections <https://onco.cc/fronts/rejuvenation/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/rejuv-agenda-biological-age-as-an-untested-target/>, <https://onco.cc/bottlenecks/b-biomarker-validation/> .