# OnCo record idea-splice-neoantigens (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-splice-neoantigens/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-splice-neoantigens" ;
  schema:name "Shared splice-derived neoantigens as off-the-shelf vaccine targets"@en ;
  schema:description "Mutations in the RNA splicing genes SF3B1, SRSF2 and U2AF1 produce the same mis-spliced proteins in patient after patient with MDS, CLL or uveal melanoma. If fragments of those proteins are displayed on common HLA molecules and seen by T cells, one off-the-shelf vaccine or TCR-T therapy could serve every SF3B1-mutant patient instead of being built per person."@en ;
  schema:url <https://onco.cc/ideas/idea-splice-neoantigens/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.ccell.2018.07.001> ;
  onco:tag "mechanism", "open-question" ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/melanoma/> ;
  onco:technologies <https://onco.cc/technologies/shared-antigen-vaccine/>, <https://onco.cc/technologies/tcr-t/>, <https://onco.cc/technologies/proteomics/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/fred-hutch/> ;
  onco:pathways <https://onco.cc/pathways/rna-splicing/>, <https://onco.cc/pathways/antigen-presentation-immunoediting/> ;
  onco:terms <https://onco.cc/terms/neoantigen/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-kahles-cancer-cell/> .