# OnCo record idea-targeting-aneuploidy (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-targeting-aneuploidy/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-targeting-aneuploidy" ;
  schema:name "Is aneuploidy itself a druggable vulnerability?"@en ;
  schema:description "Most cancers have the wrong number of chromosomes; normal cells do not. If that difference creates a specific weakness, a drug against it would spare normal tissue by definition."@en ;
  schema:url <https://onco.cc/ideas/idea-targeting-aneuploidy/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s41576-019-0171-x> ;
  onco:tag "mechanism", "open-question" ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/tnbc/> ;
  onco:targets <https://onco.cc/targets/tp53/> ;
  onco:institutions <https://onco.cc/institutions/francis-crick/>, <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/stanford/> ;
  onco:pathways <https://onco.cc/pathways/chromosomal-instability/>, <https://onco.cc/pathways/cgas-sting/> ;
  onco:terms <https://onco.cc/terms/whole-genome-doubling/> ;
  onco:trials <https://onco.cc/trials/nct03268382/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-vogelstein-surfing-p53-network-nature-2000/>, <https://onco.cc/key-papers/paper-ben-david-nat-rev-genet/> .