# OnCo record idea-tdxd-first-then-nothing (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tdxd-first-then-nothing/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tdxd-first-then-nothing" ;
  schema:name "Can T-DXd alone cure early HER2-positive disease?"@en ;
  schema:description "If Enhertu produces complete responses in two-thirds of patients before surgery, a trial should test whether some need no chemotherapy, antibodies, or even radiation afterwards."@en ;
  schema:url <https://onco.cc/ideas/idea-tdxd-first-then-nothing/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05113251>, <https://clinicaltrials.gov/study/NCT04622319> ;
  onco:cancers <https://onco.cc/cancers/breast-her2-positive/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/pertuzumab/> ;
  onco:terms <https://onco.cc/terms/pcr/> ;
  onco:trials <https://onco.cc/trials/destiny-breast11/>, <https://onco.cc/trials/destiny-breast05/>, <https://onco.cc/trials/phergain/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-trastuzumab-breast-her2-positive-n-engl-j-med-2005/>, <https://onco.cc/key-papers/paper-hera-b31-n9831-n-engl-j-med-2005/>, <https://onco.cc/key-papers/paper-trastuzumab-breast-her2-positive-n-engl-j-med-2011/> .