# OnCo record idea-tnbc-brain-metastasis-trials (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tnbc-brain-metastasis-trials/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tnbc-brain-metastasis-trials" ;
  schema:name "Trials that include, and report, brain metastases in triple-negative breast cancer"@en ;
  schema:description "Nearly half of women with metastatic triple-negative breast cancer develop brain metastases and survive under five months after the diagnosis, yet the trials that set the standard mostly exclude active brain disease. Requiring a brain metastasis cohort in every phase 3, with intracranial response as an endpoint, would answer whether the new drugs reach the brain."@en ;
  schema:url <https://onco.cc/ideas/idea-tnbc-brain-metastasis-trials/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/18833576> ;
  onco:tag "tnbc-evidence" ;
  onco:cancers <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/sacituzumab-govitecan/>, <https://onco.cc/drugs/datopotamab-deruxtecan/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:institutions <https://onco.cc/institutions/dana-farber/> ;
  onco:terms <https://onco.cc/terms/brain-metastases/> ;
  onco:trials <https://onco.cc/trials/tropion-breast05/>, <https://onco.cc/trials/izabright-breast01/>, <https://onco.cc/trials/ascent-04/> ;
  onco:people <https://onco.cc/people/nancy-lin/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/>, <https://onco.cc/bottlenecks/b-metastasis-biology/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-lin-tnbc-cns-metastases-dfci-cancer-2008/>, <https://onco.cc/key-papers/paper-tropion-breast02-ann-oncol-2026/> .