# OnCo record idea-tnbc-pd-l1-assay-harmonisation (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tnbc-pd-l1-assay-harmonisation/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tnbc-pd-l1-assay-harmonisation" ;
  schema:name "Harmonise PD-L1 testing for triple-negative breast cancer around one scored assay, with external quality assurance"@en ;
  schema:description "Three PD-L1 tests run on the same tumours called 46, 75 and 73 percent of them positive and agreed only 69 percent of the time. With atezolizumab withdrawn, pembrolizumab's test (22C3, combined positive score of 10) is the only one that matters, yet laboratories still run whichever kit they have. One assay, one score and a proficiency scheme would end answers that vary by postcode."@en ;
  schema:url <https://onco.cc/ideas/idea-tnbc-pd-l1-assay-harmonisation/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://europepmc.org/article/MED/34097070> ;
  onco:tag "tnbc-evidence" ;
  onco:cancers <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/digital-pathology-ai/>, <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/pdl1/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/ventana-pd-l1-sp142/> ;
  onco:institutions <https://onco.cc/institutions/nice/>, <https://onco.cc/institutions/asco/> ;
  onco:terms <https://onco.cc/terms/cps/>, <https://onco.cc/terms/ihc/> ;
  onco:trials <https://onco.cc/trials/keynote-355/>, <https://onco.cc/trials/impassion130/>, <https://onco.cc/trials/impassion131/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-regulatory-fragmentation/>, <https://onco.cc/bottlenecks/b-knowledge-diffusion/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-rugo-pd-l1-assay-comparison-impassion130-jnci-2021/>, <https://onco.cc/key-papers/paper-asco-biomarkers-metastatic-breast-cancer-guideline-jco-2022/>, <https://onco.cc/key-papers/paper-keynote-355-nejm-2022/> .
