# OnCo record idea-tr1-aggressive-futility-boundaries (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-aggressive-futility-boundaries/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-aggressive-futility-boundaries" ;
  schema:name "Stop failing trials earlier with pre-registered aggressive futility rules"@en ;
  schema:description "Large phase 3 trials often continue for years after interim data show the drug is unlikely to work. Pre-registering futility boundaries at 30 to 50 percent of the information, judged by independent committees and reported publicly, would stop them earlier, sparing patients and freeing money for better ideas."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-aggressive-futility-boundaries/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1136/bmj.j4530> ;
  onco:related <https://onco.cc/collections/clinicaltrials-gov/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-negative-results/>, <https://onco.cc/bottlenecks/b-funding-allocation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-davis-bmj/> .