# OnCo record idea-tr1-exposure-response-before-dose-selection (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-exposure-response-before-dose-selection/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-exposure-response-before-dose-selection" ;
  schema:name "Exposure-response modelling with a pre-set target exposure before any dose is chosen"@en ;
  schema:description "Instead of picking the dose by how much patients can tolerate, measure drug levels in blood and relate them to both benefit and harm across patients, then choose the dose that hits the sweet spot."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-exposure-response-before-dose-selection/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.fda.gov/about-fda/oncology-center-excellence/project-optimus> ;
  onco:terms <https://onco.cc/terms/pharmacokinetics/>, <https://onco.cc/terms/pivotal-trial/>, <https://onco.cc/terms/regulatory-agencies/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/> .