# OnCo record idea-tr1-intermittent-dosing-to-delay-resistance (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-intermittent-dosing-to-delay-resistance/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-intermittent-dosing-to-delay-resistance" ;
  schema:name "Test intermittent dosing of targeted drugs to delay resistance, with honest priors"@en ;
  schema:description "Giving a targeted drug in pulses rather than continuously might slow the emergence of resistant cells and reduce side effects. Early results are mixed, so this needs careful trials with clear rules for when to try it."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-intermittent-dosing-to-delay-resistance/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02196181> ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/braf/>, <https://onco.cc/targets/alk/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/ctdna/> ;
  onco:trials <https://onco.cc/trials/alex/>, <https://onco.cc/trials/cobrim/>, <https://onco.cc/trials/columbus/>, <https://onco.cc/trials/combi-ad/>, <https://onco.cc/trials/combi-d/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-chapman-vemurafenib-nejm-2011/>, <https://onco.cc/key-papers/paper-braf-melanoma-n-engl-j-med-2015/>, <https://onco.cc/key-papers/paper-alk-nsclc-n-engl-j-med-2013/> .