# OnCo record idea-tr1-pre-emptive-pharmacogenomic-testing (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-pre-emptive-pharmacogenomic-testing/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-pre-emptive-pharmacogenomic-testing" ;
  schema:name "Test DPYD, UGT1A1 and TPMT/NUDT15 before the first dose, everywhere"@en ;
  schema:description "A cheap gene test for DPYD, UGT1A1 and TPMT or NUDT15 before fluoropyrimidines, irinotecan or thiopurines identifies people at risk of severe or fatal toxicity so their dose can be lowered. The EMA has recommended DPD testing since 2020; US uptake remains partial."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-pre-emptive-pharmacogenomic-testing/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/>, <https://www.ema.europa.eu/en/medicines/human/referrals/fluorouracil-fluorouracil-related-substances-capecitabine-tegafur-flucytosine-containing-medicinal-products> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/gastric/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/topoisomerase-inhibitors/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> .