# OnCo record idea-tr1-randomised-phase-2-before-phase-3 (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-randomised-phase-2-before-phase-3/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-randomised-phase-2-before-phase-3" ;
  schema:name "Require a randomised phase 2 before any phase 3"@en ;
  schema:description "Phase 3 trials are often launched on a small single-arm response-rate study with no comparison group, and most then fail. Requiring a randomised phase 2 with a concurrent control first, with exceptions only for large effects in refractory settings, would filter out weak drugs earlier."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-randomised-phase-2-before-phase-3/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1136/bmj.j4530> ;
  onco:terms <https://onco.cc/terms/orr/>, <https://onco.cc/terms/pfs/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-negative-results/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-davis-bmj/> .