# OnCo record idea-tr1-response-adapted-dose-reduction (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-response-adapted-dose-reduction/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-response-adapted-dose-reduction" ;
  schema:name "Reduce the dose once the cancer responds: response-adapted de-escalation trials"@en ;
  schema:description "The dose needed to shrink a tumour may be higher than the dose needed to keep it from growing back. Trials that lower the dose once a response is achieved could reduce long-term side effects without losing control."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-response-adapted-dose-reduction/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.fda.gov/about-fda/oncology-center-excellence/project-optimus> ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/breast-her2-positive/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> .