# OnCo record idea-tr1-smart-designs-for-adaptive-strategies (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-smart-designs-for-adaptive-strategies/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-smart-designs-for-adaptive-strategies" ;
  schema:name "SMART designs to test treatment strategies, not just single drugs"@en ;
  schema:description "Real treatment is a series of decisions: start with this, switch to that if it fails. Sequential multiple-assignment randomised trials test whole strategies by randomising patients again at each decision point."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-smart-designs-for-adaptive-strategies/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1136/bmj.j4530> ;
  onco:related <https://onco.cc/roadmaps/prostate-roadmap/>, <https://onco.cc/ideas/idea-prostate-randomise-the-sequence-not-only-the-drugs/> ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/prostate/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/ctdna/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-davis-bmj/> .