# OnCo record idea-tr1-start-low-titrate-up-oral-agents (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-start-low-titrate-up-oral-agents/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-start-low-titrate-up-oral-agents" ;
  schema:name "Start low and step up: individualised titration of oral cancer drugs, randomised"@en ;
  schema:description "Instead of starting everyone on the full dose and cutting back after side effects, start lower and increase in patients who tolerate it. This keeps more people on treatment and is how blood-pressure drugs are given."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-start-low-titrate-up-oral-agents/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.fda.gov/about-fda/oncology-center-excellence/project-optimus> ;
  onco:technologies <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/cdk46-inhibitor/> ;
  onco:drugs <https://onco.cc/drugs/niraparib/>, <https://onco.cc/drugs/abemaciclib/>, <https://onco.cc/drugs/capivasertib/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> .