# OnCo record idea-tr1-tolerability-estimands (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr1-tolerability-estimands/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr1-tolerability-estimands" ;
  schema:name "Define tolerability endpoints as rigorously as efficacy endpoints"@en ;
  schema:description "Trials report side effects as a table of percentages that hides how long they lasted, how bad they felt and whether people stopped treatment. Tolerability should be measured with defined endpoints and a decision rule, like efficacy."@en ;
  schema:url <https://onco.cc/ideas/idea-tr1-tolerability-estimands/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://healthcaredelivery.cancer.gov/pro-ctcae/>, <https://www.ich.org/page/efficacy-guidelines> ;
  onco:terms <https://onco.cc/terms/irae/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-dose-optimisation/> .