# OnCo record idea-tr2-alternating-vs-concurrent (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-alternating-vs-concurrent/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-alternating-vs-concurrent" ;
  schema:name "Test alternating drug schedules against giving both drugs at once"@en ;
  schema:description "Two drugs might work better given in turns rather than together, with less toxicity. Almost no trial has tested this."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-alternating-vs-concurrent/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.cell.2017.11.009> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/> ;
  onco:trials <https://onco.cc/trials/flaura2/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-flaura-nejm-2018/>, <https://onco.cc/key-papers/paper-flaura2-long-term-safety-lung-cancer-2026/>, <https://onco.cc/key-papers/paper-mariposa-nejm-2024/>, <https://onco.cc/key-papers/paper-palmer-cell/> .