# OnCo record idea-tr2-antibody-validation-mandate (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-antibody-validation-mandate/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-antibody-validation-mandate" ;
  schema:name "Only use antibodies proven to hit their target with knockout controls"@en ;
  schema:description "A large fraction of commercial research antibodies fail when tested against cells engineered to lack their target, so they do not bind what the label says. Journals and funders should require knockout-validated antibodies for the claims a paper rests on, and fund public validation of the most-used cancer targets."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-antibody-validation-mandate/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://ycharos.com/> ;
  onco:related <https://onco.cc/collections/hpa/>, <https://onco.cc/ideas/idea-tr2-reagent-lot-ledger/> ;
  onco:technologies <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-reproducibility/> .