# OnCo record idea-tr2-ctdna-futility-gates (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-ctdna-futility-gates/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-ctdna-futility-gates" ;
  schema:name "Kill combination arms early using circulating tumour DNA, before waiting for scans"@en ;
  schema:description "A blood test at six weeks can show whether a treatment is doing anything. Trials should use it to drop failing combinations fast and move patients on."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-ctdna-futility-gates/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.cell.2017.11.009> ;
  onco:related <https://onco.cc/companies/guardant-health/>, <https://onco.cc/companies/natera/>, <https://onco.cc/ideas/idea-cd8-pet-io/> ;
  onco:technologies <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:terms <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/recist/>, <https://onco.cc/terms/pfs/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-palmer-cell/> .