# OnCo record idea-tr2-cutpoint-lock (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-cutpoint-lock/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-cutpoint-lock" ;
  schema:name "Lock the biomarker cut-off before phase 3, and publish it"@en ;
  schema:description "Companies sometimes choose the biomarker threshold that makes their trial look best after seeing the data. Requiring the threshold to be fixed and published before the big trial starts prevents this."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-cutpoint-lock/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamaoncol.2021.7239> ;
  onco:related <https://onco.cc/ideas/idea-tr2-marker-stratified-default/> ;
  onco:targets <https://onco.cc/targets/pdl1/> ;
  onco:terms <https://onco.cc/terms/companion-diagnostic-term/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-fernandez-jama-oncol/> .