# OnCo record idea-tr2-her2-low-reference-materials (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-her2-low-reference-materials/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-her2-low-reference-materials" ;
  schema:name "Calibrated reference slides so every lab scores HER2-low the same way"@en ;
  schema:description "Whether a breast cancer counts as HER2-low, and so qualifies for trastuzumab deruxtecan, turns on the least reproducible step of the HER2 stain, score 1+ versus 0. Cell-line microarrays with a known quantity of HER2 protein per cell, run alongside clinical slides, would anchor every laboratory to a physical standard."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-her2-low-reference-materials/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.nordiqc.org/> ;
  onco:related <https://onco.cc/terms/her2-low/>, <https://onco.cc/ideas/idea-ai-her2-low-scoring/> ;
  onco:technologies <https://onco.cc/technologies/histopathology-ihc/>, <https://onco.cc/technologies/digital-pathology-ai/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/> ;
  onco:terms <https://onco.cc/terms/ihc/> ;
  onco:trials <https://onco.cc/trials/destiny-breast04/>, <https://onco.cc/trials/destiny-breast06/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-destiny-breast06-nejm-2024/> .