# OnCo record idea-tr2-marker-stratified-default (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-marker-stratified-default/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-marker-stratified-default" ;
  schema:name "Test the drug in biomarker-negative patients too, so the biomarker can be validated"@en ;
  schema:description "Trials that only enrol patients with a positive biomarker can never prove the biomarker matters. Including a smaller biomarker-negative group would show whether the test is really needed."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-marker-stratified-default/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamaoncol.2021.7239> ;
  onco:related <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/her2-low/>, <https://onco.cc/ideas/idea-tr2-biomarker-negative-arms/> ;
  onco:technologies <https://onco.cc/technologies/companion-diagnostic/> ;
  onco:terms <https://onco.cc/terms/companion-diagnostic-term/>, <https://onco.cc/terms/hazard-ratio/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-trial-design/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-fernandez-jama-oncol/> .