# OnCo record idea-tr2-neoadjuvant-combo-platform (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-neoadjuvant-combo-platform/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-neoadjuvant-combo-platform" ;
  schema:name "Pre-surgery platform trials that test combinations on pathological response in months"@en ;
  schema:description "Give drug combinations before surgery and measure how much tumour remains at resection; that answer arrives in months. A standing neoadjuvant platform with a shared control arm, as I-SPY 2 runs in breast cancer, would test combinations quickly in lung, bladder, melanoma, head and neck and oesophago-gastric cancer."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-neoadjuvant-combo-platform/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.ispytrials.org/> ;
  onco:related <https://onco.cc/terms/major-pathological-response/>, <https://onco.cc/pairings/neoadjuvant-io-response-adapted/> ;
  onco:cancers <https://onco.cc/cancers/esophageal/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/melanoma/> ;
  onco:terms <https://onco.cc/terms/pcr/>, <https://onco.cc/terms/rcb/>, <https://onco.cc/terms/basket-umbrella-platform/> ;
  onco:trials <https://onco.cc/trials/keynote-522/>, <https://onco.cc/trials/nadina/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-trial-design/> .