# OnCo record idea-tr2-positivity-rate-surveillance (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-positivity-rate-surveillance/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-positivity-rate-surveillance" ;
  schema:name "Monitor biomarker positivity rates across labs in real time to catch assay drift"@en ;
  schema:description "If one lab suddenly reports twice the rate of 'positive' biomarker results that other labs report, its assay has probably drifted. Pooling anonymised positivity rates by laboratory, assay and version, with automated outlier detection and case-mix adjustment, would catch reagent lot problems and protocol drift within weeks rather than at occasional proficiency runs."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-positivity-rate-surveillance/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamaoncol.2021.7239> ;
  onco:related <https://onco.cc/ideas/idea-tr2-eqa-public-results/>, <https://onco.cc/ideas/idea-tr2-ai-cdx-change-control/> ;
  onco:technologies <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-data-silos/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-fernandez-jama-oncol/> .