# OnCo record idea-tr2-prospective-retrospective-path (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-prospective-retrospective-path/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-prospective-retrospective-path" ;
  schema:name "A formal regulatory route for validating a biomarker on archived trial samples"@en ;
  schema:description "Completed trials have stored samples. Testing a new biomarker on them with the plan written in advance is nearly as good as a new trial and far cheaper, but regulators have no clear route to accept it."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-prospective-retrospective-path/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1001/jamaoncol.2021.7239> ;
  onco:related <https://onco.cc/ideas/idea-tr2-failed-trial-biobank/>, <https://onco.cc/trials/tailorx/>, <https://onco.cc/trials/rxponder/> ;
  onco:drugs <https://onco.cc/drugs/oncotype-dx/> ;
  onco:terms <https://onco.cc/terms/companion-diagnostic-term/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-biomarker-validation/>, <https://onco.cc/bottlenecks/b-negative-results/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-fernandez-jama-oncol/> .