# OnCo record idea-tr2-rwe-combination-emulation (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-rwe-combination-emulation/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-rwe-combination-emulation" ;
  schema:name "Emulate combination trials from real-world data to triage which ones to run"@en ;
  schema:description "Combinations used off-label in over 200 patients in clinico-genomic databases can be analysed by target trial emulation. Emulations cannot replace trials, but they can rule out the pairs with no signal and flag those with large effects before money is spent on randomised studies."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-rwe-combination-emulation/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.cell.2017.11.009> ;
  onco:related <https://onco.cc/companies/tempus/>, <https://onco.cc/companies/foundation-medicine/>, <https://onco.cc/collections/genie/> ;
  onco:terms <https://onco.cc/terms/real-world-evidence/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-real-world-evidence/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-palmer-cell/> .