# OnCo record idea-tr2-smart-sequencing-adc (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-tr2-smart-sequencing-adc/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-tr2-smart-sequencing-adc" ;
  schema:name "Sequential multiple-assignment randomised trials to find the best order of ADCs"@en ;
  schema:description "Patients are randomised at each decision point, not just at the start, so one trial can compare whole treatment sequences rather than single drugs."@en ;
  schema:url <https://onco.cc/ideas/idea-tr2-smart-sequencing-adc/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://doi.org/10.1016/j.cell.2017.11.009> ;
  onco:related <https://onco.cc/ideas/idea-payload-switching/>, <https://onco.cc/ideas/idea-her2-adc-sequencing-payload/>, <https://onco.cc/pairings/adc-after-adc-caution/> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/sacituzumab-govitecan/>, <https://onco.cc/drugs/datopotamab-deruxtecan/> ;
  onco:terms <https://onco.cc/terms/adc-sequencing/>, <https://onco.cc/terms/efflux-pump/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-combination-space/>, <https://onco.cc/bottlenecks/b-resistance/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-palmer-cell/> .