# OnCo record idea-upgrade-oral-cryotherapy-with-bolus-chemotherapy (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-upgrade-oral-cryotherapy-with-bolus-chemotherapy/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-upgrade-oral-cryotherapy-with-bolus-chemotherapy" ;
  schema:name "Ice chips in the chair for every bolus fluorouracil and high-dose melphalan infusion"@en ;
  schema:description "Holding ice chips in the mouth for half an hour around a quick injection of fluorouracil, or high-dose melphalan before a stem cell transplant, cools the mouth while the drug level peaks. A review of 14 trials found it prevents mouth ulcers in about one in four people given fluorouracil, and a guideline recommends it. How often it is offered is not measured."@en ;
  schema:url <https://onco.cc/ideas/idea-upgrade-oral-cryotherapy-with-bolus-chemotherapy/> ;
  schema:dateModified "2026-10-20"^^xsd:date ;
  schema:citation <https://doi.org/10.1002/14651858.CD011552.pub2>, <https://doi.org/10.1002/cncr.33100> ;
  onco:tag "protocol-upgrade", "upgrade:proven-unevenly-used", "evidence:strong" ;
  onco:related <https://onco.cc/ideas/idea-moon-mucositis-taste-programme/> ;
  onco:sections <https://onco.cc/fronts/supportive-care/>, <https://onco.cc/fronts/chemotherapy/> ;
  onco:technologies <https://onco.cc/technologies/oral-cryotherapy-mucositis/> ;
  onco:drugs <https://onco.cc/drugs/fluorouracil/>, <https://onco.cc/drugs/melphalan/> ;
  onco:terms <https://onco.cc/terms/mucositis/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-knowledge-diffusion/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-riley-cochrane-database-syst-rev/>, <https://onco.cc/key-papers/paper-elad-cancer/> .