# OnCo record idea-upgrade-topical-diclofenac-during-capecitabine (idea). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/ideas/idea-upgrade-topical-diclofenac-during-capecitabine/>
  a schema:CreativeWork ;
  onco:kind "idea" ;
  schema:identifier "idea-upgrade-topical-diclofenac-during-capecitabine" ;
  schema:name "Anti-inflammatory gel on the palms and soles from the first day of capecitabine"@en ;
  schema:description "Capecitabine often makes the hands and feet sore and peeling, and the usual answer is a lower dose. In one randomised trial, a cheap diclofenac gel rubbed on the palms cut moderate or worse hand-foot syndrome from 15 to under 4 per cent and halved dose cuts. A later study in routine care found no benefit, and a larger Japanese trial on palms and soles is under way."@en ;
  schema:url <https://onco.cc/ideas/idea-upgrade-topical-diclofenac-during-capecitabine/> ;
  schema:dateModified "2026-11-11"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/jco.23.01730>, <https://doi.org/10.1136/spcare-2025-005639>, <https://doi.org/10.1200/go-26-00151>, <https://doi.org/10.1007/s10147-025-02789-z> ;
  onco:tag "protocol-upgrade", "upgrade:promising", "evidence:moderate" ;
  onco:sections <https://onco.cc/fronts/supportive-care/> ;
  onco:drugs <https://onco.cc/drugs/capecitabine/> ;
  onco:terms <https://onco.cc/terms/hand-foot-syndrome/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/> .