# OnCo record idh-2hg (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/idh-2hg/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "idh-2hg" ;
  schema:name "Mutant IDH / 2-hydroxyglutarate"@en ;
  schema:description "A single mutation in a metabolic enzyme (IDH1 or IDH2) makes cells pour out a molecule they should never make, 2-hydroxyglutarate. It jams the machinery that erases chemical marks on DNA and histones, so blood and brain cells get stuck before they mature. Pills that block the mutant enzyme let them mature again."@en ;
  schema:url <https://onco.cc/pathways/idh-2hg/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase> ;
  schema:citation <https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/mds/> ;
  onco:targets <https://onco.cc/targets/idh/> ;
  onco:drugs <https://onco.cc/drugs/ivosidenib/>, <https://onco.cc/drugs/olutasidenib/>, <https://onco.cc/drugs/enasidenib/>, <https://onco.cc/drugs/vorasidenib/> ;
  onco:pathways <https://onco.cc/pathways/epigenetic-reprogramming/> ;
  onco:trials <https://onco.cc/trials/indigo/> .