# OnCo record idh (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/idh/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "idh" ;
  schema:name "IDH1 / IDH2"@en ;
  schema:description "A metabolic enzyme whose mutant form produces a molecule that scrambles how genes are read; blocking it slows brain tumours and leukaemias."@en ;
  schema:url <https://onco.cc/targets/idh/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase> ;
  owl:sameAs <http://www.wikidata.org/entity/Q261968> ;
  schema:citation <https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase> ;
  onco:tag "driver", "epigenetic" ;
  schema:alternateName "IDH1, IDH2" ;
  onco:targetClass "enzyme" ;
  onco:related <https://onco.cc/biomarkers/idh1-r132/>, <https://onco.cc/biomarkers/idh2-mutation/> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/prostate/> ;
  onco:drugs <https://onco.cc/drugs/oncomine-dx-target-test/>, <https://onco.cc/drugs/tqb3454/>, <https://onco.cc/drugs/hmpl-306/>, <https://onco.cc/drugs/safusidenib/> ;
  onco:pathways <https://onco.cc/pathways/glioma-signalling/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-javle-biliary-ngs-cancer-2016/>, <https://onco.cc/key-papers/paper-tcga-molecular-taxonomy-primary-prostate-cell-2015/> .