# OnCo record idh2-mutation (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/idh2-mutation/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "idh2-mutation" ;
  schema:name "IDH2 mutation (R140 and R172)"@en ;
  schema:alternateName "IDH2 R140Q"@en, "IDH2 R172K"@en, "IDH2 mutation"@en, "IDH2-mutant"@en, "mIDH2"@en ;
  schema:description "IDH2 mutations at codons 140 and 172 do the same job as IDH1 R132, producing 2-HG. Enasidenib is approved for relapsed AML with them, and vorasidenib for grade 2 gliomas with either IDH gene mutated."@en ;
  schema:url <https://onco.cc/biomarkers/idh2-mutation/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a5b4cdf0-3fa8-4c6c-80f6-8d8a00e3a5b6> ;
  onco:tag "biomarker", "idh" ;
  onco:related <https://onco.cc/biomarkers/idh1-r132/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/aml-idh/>, <https://onco.cc/cancers/idh-mutant-astrocytoma/>, <https://onco.cc/cancers/oligodendroglioma/> ;
  onco:drugs <https://onco.cc/drugs/enasidenib/>, <https://onco.cc/drugs/vorasidenib/> ;
  onco:terms <https://onco.cc/terms/ngs/> .