# OnCo record ido1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/ido1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "ido1" ;
  schema:name "IDO1"@en ;
  schema:alternateName "IDO"@en, "INDO"@en, "indoleamine 2,3-dioxygenase 1"@en, "IDO1" ;
  schema:description "IDO1 is an enzyme tumours use to burn up tryptophan, starving T cells and producing by-products that switch them off. Epacadostat blocked it but its programme ended in failure; the IO102-IO103 vaccine instead teaches T cells to attack the IDO1-expressing cells themselves."@en ;
  schema:url <https://onco.cc/targets/ido1/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6059>, <https://www.uniprot.org/uniprotkb/P14902/entry>, <https://www.ncbi.nlm.nih.gov/gene/3620> ;
  onco:tag "wave5-target" ;
  onco:targetClass "enzyme" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6059>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000131203>, <https://www.uniprot.org/uniprotkb/P14902/entry>, <https://www.ncbi.nlm.nih.gov/gene/3620> ;
  onco:related <https://onco.cc/targets/pdl1/> ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/head-and-neck/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:drugs <https://onco.cc/drugs/epacadostat/>, <https://onco.cc/drugs/io102-io103/> ;
  onco:pathways <https://onco.cc/pathways/nutrient-competition-tme/>, <https://onco.cc/pathways/immune-desert-exclusion/>, <https://onco.cc/pathways/cancer-immunity-cycle/> .