# OnCo record iec-hs (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/iec-hs/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "iec-hs" ;
  schema:name "IEC-HS (immune effector cell-associated HLH-like syndrome)"@en ;
  schema:alternateName "IEC-HS"@en, "Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome"@en, "HLH-like syndrome after CAR-T"@en ;
  schema:description "IEC-HS is a rare, serious overreaction of the immune system after CAR-T cell treatment. It usually comes as the first reaction (cytokine release syndrome) is settling, and shows as very high ferritin, falling blood counts, clotting problems and liver changes. It is treated with drugs that calm the immune system."@en ;
  schema:url <https://onco.cc/terms/iec-hs/> ;
  schema:dateModified "2026-11-11"^^xsd:date ;
  schema:citation <https://pmc.ncbi.nlm.nih.gov/articles/PMC10330221/> ;
  onco:tag "supportive-care-gaps-2026-11" ;
  onco:technologies <https://onco.cc/technologies/car-t/> ;
  onco:drugs <https://onco.cc/drugs/emapalumab/>, <https://onco.cc/drugs/ruxolitinib/> ;
  onco:terms <https://onco.cc/terms/crs/>, <https://onco.cc/terms/icans/> .