# OnCo record ikzf1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/ikzf1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "ikzf1" ;
  schema:name "IKZF1 (Ikaros)"@en ;
  schema:alternateName "Ikaros"@en, "IKAROS"@en, "ZNFN1A1"@en, "IKAROS family zinc finger 1"@en, "IKZF1" ;
  schema:description "Ikaros is a transcription factor that myeloma cells depend on. Lenalidomide, pomalidomide and the newer CELMoDs work by gluing Ikaros to the cell's disposal machinery so it is destroyed, which kills the plasma cell and wakes up T cells."@en ;
  schema:url <https://onco.cc/targets/ikzf1/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13176>, <https://www.uniprot.org/uniprotkb/Q13422/entry>, <https://www.ncbi.nlm.nih.gov/gene/10320> ;
  onco:tag "wave5-target" ;
  onco:targetClass "transcription" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13176>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185811>, <https://www.uniprot.org/uniprotkb/Q13422/entry>, <https://www.ncbi.nlm.nih.gov/gene/10320> ;
  onco:related <https://onco.cc/targets/cereblon/>, <https://onco.cc/targets/ikzf3/>, <https://onco.cc/targets/irf4/>, <https://onco.cc/pathways/myc/> ;
  onco:cancers <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/dlbcl/> ;
  onco:technologies <https://onco.cc/technologies/celmods/>, <https://onco.cc/technologies/molecular-glue-platforms/> ;
  onco:drugs <https://onco.cc/drugs/lenalidomide/>, <https://onco.cc/drugs/pomalidomide/>, <https://onco.cc/drugs/thalidomide/>, <https://onco.cc/drugs/golcadomide/> ;
  onco:pathways <https://onco.cc/pathways/ubiquitin-proteasome-system/>, <https://onco.cc/pathways/transcription-addiction/> .