# OnCo record ikzf3 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/ikzf3/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "ikzf3" ;
  schema:name "IKZF3 (Aiolos)"@en ;
  schema:alternateName "Aiolos"@en, "ZNFN1A3"@en, "IKAROS family zinc finger 3"@en, "IKZF3" ;
  schema:description "Aiolos is Ikaros' partner transcription factor in B cells and plasma cells. The myeloma drugs lenalidomide, pomalidomide and golcadomide destroy Aiolos and Ikaros together by rerouting them to the cell's protein-disposal system."@en ;
  schema:url <https://onco.cc/targets/ikzf3/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13178>, <https://www.uniprot.org/uniprotkb/Q9UKT9/entry>, <https://www.ncbi.nlm.nih.gov/gene/22806> ;
  onco:tag "wave5-target" ;
  onco:targetClass "transcription" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13178>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000161405>, <https://www.uniprot.org/uniprotkb/Q9UKT9/entry>, <https://www.ncbi.nlm.nih.gov/gene/22806> ;
  onco:related <https://onco.cc/targets/cereblon/>, <https://onco.cc/targets/ikzf1/>, <https://onco.cc/targets/irf4/>, <https://onco.cc/targets/bcl2/> ;
  onco:cancers <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/myeloma-relapsed-refractory/>, <https://onco.cc/cancers/dlbcl/> ;
  onco:technologies <https://onco.cc/technologies/celmods/>, <https://onco.cc/technologies/molecular-glue-platforms/> ;
  onco:drugs <https://onco.cc/drugs/lenalidomide/>, <https://onco.cc/drugs/pomalidomide/>, <https://onco.cc/drugs/golcadomide/> ;
  onco:pathways <https://onco.cc/pathways/ubiquitin-proteasome-system/>, <https://onco.cc/pathways/transcription-addiction/> .