# OnCo record imblaze370 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/imblaze370/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "imblaze370", "NCT02788279" ;
  schema:name "IMblaze370"@en ;
  schema:alternateName "COTEZO"@en ;
  schema:description "The trial that tried to make immunotherapy work in ordinary bowel cancer by adding a MEK inhibitor. It failed outright."@en ;
  schema:url <https://onco.cc/trials/imblaze370/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02788279>, <https://doi.org/10.1016/S1470-2045(19)30027-0> ;
  onco:status "negative" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/mek/> ;
  onco:drugs <https://onco.cc/drugs/atezolizumab/>, <https://onco.cc/drugs/cobimetinib/>, <https://onco.cc/drugs/regorafenib/> ;
  onco:companies <https://onco.cc/companies/roche-genentech/> ;
  onco:terms <https://onco.cc/terms/msi/>, <https://onco.cc/terms/cold-vs-hot/> .