# OnCo record immune-checkpoint (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/immune-checkpoint/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "immune-checkpoint" ;
  schema:name "Immune checkpoint"@en ;
  schema:alternateName "immune checkpoints"@en, "checkpoint protein"@en, "checkpoint proteins"@en, "checkpoint blockade"@en, "immune checkpoint blockade"@en, "checkpoint inhibition"@en, "checkpoint inhibitor"@en, "checkpoint inhibitors"@en, "immune checkpoint inhibitor"@en, "immune checkpoint inhibitors"@en, "ICI"@en, "ICIs"@en, "PD-1 blockade"@en, "PD-1/PD-L1"@en, "anti-PD-1"@en, "anti-PD-L1"@en, "anti-CTLA-4"@en, "PD-(L)1"@en ;
  schema:description "Brakes on the immune system that stop T cells attacking healthy tissue. Tumours pull these brakes to protect themselves; checkpoint inhibitor drugs release them so T cells can attack the cancer."@en ;
  schema:url <https://onco.cc/terms/immune-checkpoint/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Immune_checkpoint> ;
  owl:sameAs <http://www.wikidata.org/entity/Q21686041> ;
  schema:citation <https://en.wikipedia.org/wiki/Immune_checkpoint> ;
  onco:related <https://onco.cc/terms/checkpoint/>, <https://onco.cc/terms/t-cell/>, <https://onco.cc/terms/immune-system/>, <https://onco.cc/terms/immunotherapy-term/>, <https://onco.cc/terms/irae/>, <https://onco.cc/terms/cold-vs-hot/>, <https://onco.cc/terms/cps/>, <https://onco.cc/terms/avoiding-immune-destruction/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/pdl1/>, <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/lag3/>, <https://onco.cc/targets/tigit/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/>, <https://onco.cc/drugs/atezolizumab/>, <https://onco.cc/drugs/durvalumab/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/> .