# OnCo record immune-stimulating-adc (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/immune-stimulating-adc/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "immune-stimulating-adc" ;
  schema:name "Immune-stimulating antibody conjugate (ISAC)"@en ;
  schema:description "An immune-stimulating antibody conjugate (ISAC) is an ADC whose payload wakes up the immune system inside the tumour rather than poisoning the cell."@en ;
  schema:url <https://onco.cc/technologies/immune-stimulating-adc/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/s43018-020-00136-x> ;
  onco:status "phase-1" ;
  onco:tag "frontier" ;
  onco:sections <https://onco.cc/fronts/adcs/>, <https://onco.cc/fronts/immunotherapy/> ;
  onco:technologies <https://onco.cc/technologies/adc/>, <https://onco.cc/technologies/sting-agonist/> ;
  onco:companies <https://onco.cc/companies/nbe-therapeutics/>, <https://onco.cc/companies/tallac-therapeutics/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-ackerman-nat-cancer/> .