# OnCo record impdh2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/impdh2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "impdh2" ;
  schema:name "IMP dehydrogenase (IMPDH2)"@en ;
  schema:description "IMPDH is the bottleneck enzyme for making guanine nucleotides; mycophenolate blocks it to hold back the donor T cells that cause graft-versus-host disease after stem cell transplantation, and the enzyme is over-expressed in fast-growing tumours."@en ;
  schema:url <https://onco.cc/targets/impdh2/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/IMP_dehydrogenase>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6053>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178035>, <https://www.uniprot.org/uniprotkb/P12268/entry>, <https://www.ncbi.nlm.nih.gov/gene/3615> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P12268/entry>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6053>, <https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2111369> ;
  onco:tag "chembl-gap" ;
  schema:alternateName "IMPDH2" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1988"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/dhfr/>, <https://onco.cc/targets/gart/> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/sclc/> ;
  onco:terms <https://onco.cc/terms/gvhd/> .