# OnCo record inca033989 (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/inca033989/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "inca033989" ;
  schema:name "INCA033989"@en ;
  schema:alternateName "INCA-033989"@en, "Mutant-CALR antibody"@en ;
  schema:description "INCA033989 is an antibody that recognises only the mutant form of calreticulin found in about a quarter of essential thrombocythaemia and myelofibrosis patients. Unlike existing drugs, which control counts, it targets the diseased clone itself and is in first-in-human trials."@en ;
  schema:url <https://onco.cc/drugs/inca033989/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  onco:status "phase-1" ;
  onco:tag "subtype-drugs-wave" ;
  onco:modality "Monoclonal antibody against mutant calreticulin" ;
  onco:related <https://onco.cc/drugs/ruxolitinib/> ;
  onco:cancers <https://onco.cc/cancers/essential-thrombocythaemia/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/jak2/> ;
  onco:companies <https://onco.cc/companies/incyte/> .