# OnCo record intermittent-androgen-deprivation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/intermittent-androgen-deprivation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "intermittent-androgen-deprivation" ;
  schema:name "Intermittent androgen deprivation (IAD)"@en ;
  schema:alternateName "IAD"@en, "IADT"@en, "intermittent hormone therapy"@en, "intermittent androgen suppression"@en, "treatment holiday"@en, "hormone therapy break"@en ;
  schema:description "Taking planned breaks from hormone therapy once the PSA has settled, restarting when it rises again. The aim is to give a man time back with his energy, his libido and his mood. The largest trial found the benefit was real but lasted about three months, and could not rule out a worse chance of survival."@en ;
  schema:url <https://onco.cc/terms/intermittent-androgen-deprivation/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://www.nice.org.uk/guidance/ng131/chapter/Recommendations>, <https://doi.org/10.1056/nejmoa1212299> ;
  onco:tag "gu", "prostate-glossary" ;
  onco:related <https://onco.cc/key-papers/paper-hussain-swog-9346-intermittent-androgen-deprivation-nejm-2013/>, <https://onco.cc/terms/androgen-deprivation-therapy/>, <https://onco.cc/terms/bipolar-androgen-therapy/>, <https://onco.cc/ideas/idea-prostate-other-cause-mortality-as-a-reported-service-outcome/>, <https://onco.cc/ideas/idea-bio1-alternating-schedules/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mhspc/>, <https://onco.cc/cancers/prostate-bcr/>, <https://onco.cc/cancers/prostate-high-risk/> ;
  onco:sections <https://onco.cc/fronts/hormonal/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/> ;
  onco:drugs <https://onco.cc/drugs/leuprolide/>, <https://onco.cc/drugs/bicalutamide/> ;
  onco:terms <https://onco.cc/terms/adt/>, <https://onco.cc/terms/androgen-deprivation-therapy/>, <https://onco.cc/terms/psa/>, <https://onco.cc/terms/quality-of-life/>, <https://onco.cc/terms/hazard-ratio/>, <https://onco.cc/terms/bipolar-androgen-therapy/>, <https://onco.cc/terms/hot-flushes-on-hormone-therapy/>, <https://onco.cc/terms/treatment-induced-bone-loss/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-trial-design/>, <https://onco.cc/bottlenecks/b-survivorship/>, <https://onco.cc/bottlenecks/b-aging-comorbidity/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-hussain-swog-9346-intermittent-androgen-deprivation-nejm-2013/>, <https://onco.cc/key-papers/paper-langley-lancet/> .