# OnCo record intismeran-autogene (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/intismeran-autogene/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "intismeran-autogene" ;
  schema:name "Intismeran autogene"@en ;
  schema:alternateName "mRNA-4157"@en, "V940"@en, "personalised cancer vaccine (PCV)"@en, "individualised neoantigen therapy (INT)"@en ;
  schema:description "A custom mRNA vaccine encoding up to 34 of a patient's own tumour mutations. In August 2026 it became the first personalised cancer vaccine to win a phase 3 trial."@en ;
  schema:url <https://onco.cc/drugs/intismeran-autogene/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://www.merck.com/news/merck-and-moderna-announce-phase-3-interpath-001-trial-of-intismeran-autogene-plus-keytruda-met-endpoints-of-recurrence-free-survival-rfs-and-distant-metastasis-free-survival-dmfs-in-patient/> ;
  onco:status "phase-3" ;
  onco:modality "Personalised mRNA neoantigen vaccine" ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/stage-iii-melanoma/>, <https://onco.cc/cancers/stage-ii-melanoma/> ;
  onco:technologies <https://onco.cc/technologies/neoantigen-mrna-vaccine/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/> ;
  onco:companies <https://onco.cc/companies/moderna/>, <https://onco.cc/companies/merck/> ;
  onco:trials <https://onco.cc/trials/interpath-001/>, <https://onco.cc/trials/nct06077760/>, <https://onco.cc/trials/nct07513376/>, <https://onco.cc/trials/nct03897881/>, <https://onco.cc/trials/nct07221474/>, <https://onco.cc/trials/nct06307431/>, <https://onco.cc/trials/nct06961006/>, <https://onco.cc/trials/nct06623422/>, <https://onco.cc/trials/nct06305767/>, <https://onco.cc/trials/nct06833073/> .