# OnCo record invasion-ecm-degradation (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/invasion-ecm-degradation/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "invasion-ecm-degradation" ;
  schema:name "Invasion: proteases, adhesion & the invasive front"@en ;
  schema:description "To invade, a cancer cell must grip the scaffolding around it, dissolve a path with enzymes, and pull itself forward, alone or in a chain led by a scout cell. Fibroblasts often cut the trail first. The enzyme blockers of the 1990s failed; today's targets are the grip (integrins, FAK) and the trail-makers."@en ;
  schema:url <https://onco.cc/pathways/invasion-ecm-degradation/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Invadopodia> ;
  schema:citation <https://doi.org/10.1016/j.cell.2011.11.016> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/terms/lgsoc/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/head-and-neck/> ;
  onco:technologies <https://onco.cc/technologies/fluorescence-guided-surgery/>, <https://onco.cc/technologies/robotic-surgery/>, <https://onco.cc/technologies/mechanobiology-therapy/>, <https://onco.cc/technologies/fapi-pet/>, <https://onco.cc/technologies/single-cell-spatial/>, <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:targets <https://onco.cc/targets/fap/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/met/>, <https://onco.cc/targets/smoothened/>, <https://onco.cc/targets/fak/> ;
  onco:drugs <https://onco.cc/drugs/avutometinib-defactinib/>, <https://onco.cc/drugs/fap-2286/> ;
  onco:pathways <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/basement-membrane-tissue-barriers/>, <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/hippo-yap/>, <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/pathways/metastatic-cascade/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/>, <https://onco.cc/terms/cancer-associated-fibroblasts/>, <https://onco.cc/terms/tnm-staging/>, <https://onco.cc/terms/activating-invasion-metastasis/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-friedl-cell/> .