# OnCo record io-first-then-braf-mek (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/io-first-then-braf-mek/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "io-first-then-braf-mek" ;
  schema:name "Immunotherapy first, then BRAF/MEK (BRAF-mutant melanoma)"@en ;
  schema:description "In BRAF-mutant melanoma, start with immunotherapy and keep the targeted pills in reserve; the reverse order costs lives."@en ;
  schema:url <https://onco.cc/pairings/io-first-then-braf-mek/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02224781> ;
  onco:cancers <https://onco.cc/cancers/melanoma/> ;
  onco:targets <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/>, <https://onco.cc/drugs/dabrafenib-trametinib/>, <https://onco.cc/drugs/encorafenib/> ;
  onco:trials <https://onco.cc/trials/dreamseq/> ;
  onco:pairs <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/drugs/dabrafenib-trametinib/> .