# OnCo record io-plus-vegf (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/io-plus-vegf/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "io-plus-vegf" ;
  schema:name "PD-1 blockade + VEGF inhibition"@en ;
  schema:description "Normalising the tumour's blood vessels lets immune cells in, and VEGF blockade removes an immunosuppressive signal."@en ;
  schema:url <https://onco.cc/pairings/io-plus-vegf/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2035716>, <https://clinicaltrials.gov/study/NCT05499390> ;
  onco:cancers <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/hcc/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/nsclc/> ;
  onco:drugs <https://onco.cc/drugs/ivonescimab/>, <https://onco.cc/drugs/atezolizumab/>, <https://onco.cc/drugs/pembrolizumab/> ;
  onco:pathways <https://onco.cc/pathways/vegf-angiogenesis/>, <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:pairs <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/antiangiogenic/> .