# OnCo record io-rechallenge-caution-rcc (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/io-rechallenge-caution-rcc/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "io-rechallenge-caution-rcc" ;
  schema:name "Caution: PD-1 rechallenge after progression on immunotherapy (RCC)"@en ;
  schema:description "Restarting immunotherapy alongside a targeted pill after immunotherapy has already failed adds side effects and no benefit."@en ;
  schema:url <https://onco.cc/pairings/io-rechallenge-caution-rcc/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04338269>, <https://clinicaltrials.gov/study/NCT04987203> ;
  onco:cancers <https://onco.cc/cancers/rcc/> ;
  onco:drugs <https://onco.cc/drugs/atezolizumab/>, <https://onco.cc/drugs/cabozantinib/>, <https://onco.cc/drugs/tivozanib/>, <https://onco.cc/drugs/nivolumab/> ;
  onco:trials <https://onco.cc/trials/contact-03/>, <https://onco.cc/trials/tinivo-2/> ;
  onco:pairs <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/antiangiogenic/> .