# OnCo record io-then-til (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/io-then-til/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "io-then-til" ;
  schema:name "PD-1 failure → TIL therapy"@en ;
  schema:description "When checkpoint blockade fails in melanoma, harvesting and expanding the patient's own tumour-reactive T cells still works in a third of patients."@en ;
  schema:url <https://onco.cc/pairings/io-then-til/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02360579> ;
  onco:cancers <https://onco.cc/cancers/melanoma/> ;
  onco:drugs <https://onco.cc/drugs/lifileucel/>, <https://onco.cc/drugs/pembrolizumab/> ;
  onco:pairs <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/til-therapy/> .