# OnCo record irae-nephritis (protocol). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/protocols/irae-nephritis/>
  a schema:MedicalGuideline ;
  onco:kind "protocol" ;
  schema:identifier "irae-nephritis" ;
  schema:name "Kidney inflammation (immune-related nephritis) from checkpoint inhibitors"@en ;
  schema:alternateName "checkpoint inhibitor nephritis"@en, "ICI-associated acute kidney injury"@en, "ICI-AKI"@en, "immune-related acute interstitial nephritis"@en, "checkpoint inhibitor tubulointerstitial nephritis"@en, "immunotherapy kidney damage"@en ;
  schema:description "Immunotherapy can occasionally inflame the kidneys. It usually causes no symptoms and is found when the creatinine on a routine blood test rises. Other causes are looked for first, some medicines may be stopped, immunotherapy is paused, and steroids are given if the immunotherapy is the cause. Some people can later restart."@en ;
  schema:url <https://onco.cc/protocols/irae-nephritis/> ;
  schema:dateModified "2026-11-11"^^xsd:date ;
  onco:tag "protocol", "irae", "nephrology" ;
  onco:related <https://onco.cc/protocols/irae-rechallenge/>, <https://onco.cc/protocols/checkpoint-inhibitor-baseline-and-monitoring/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/>, <https://onco.cc/drugs/atezolizumab/>, <https://onco.cc/drugs/durvalumab/>, <https://onco.cc/drugs/cemiplimab/>, <https://onco.cc/drugs/tremelimumab/>, <https://onco.cc/drugs/avelumab/>, <https://onco.cc/drugs/dostarlimab/> ;
  onco:institutions <https://onco.cc/institutions/sitc/>, <https://onco.cc/institutions/asco/>, <https://onco.cc/institutions/esmo/> ;
  onco:terms <https://onco.cc/terms/irae/>, <https://onco.cc/terms/rechallenge/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-asco-irae-guideline-jco-2021/> .